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KMID : 0615720150320020065
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Jouranl of Korean Acupuncture and Moxibustion society
2015 Volume.32 No. 2 p.65 ~ p.75
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The Effects of Warm Needling at GB30·GB34 on Complete Freund’s Adjuvant(CFA)-induced Rheumatoid Arthritis in Rats
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Jeong Joo-Yong
Cho Myoung-Rae
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Abstract
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Objectives: The purpose of this study was to investigate the effects of warm needling at GB30·GB34 on Complete Freund’s Adjuvant(CFA)-induced rheumatoid arthritis in rats.
Methods: Arthritis was induced by injecting CFA subcutaneously into the left knee joint and paw. Acupuncture(AT) and warm needling(W-AT0.5, W-AT1.0) were injected at GB30·GB34, every other day for a total of 5 times beginning on day 10 after the CFA injection. Thereafter, external shape, paw edema, serum aminotransferase and anti-inflammatory factors were assessed, and hematological and histological observations were made.
Results:In paw edema volume all 3 groups(AT, W-AT0.5, W-AT1.0) showed significant decrease compared to the CFA control group. In TNF-α and IL-6, all 3 groups showed significant decrease compared to CFA control group. In AST and ALT all 3 groups showed no significant change. In IL-1β, W-AT0.5 and W-AT1.0, groups showed significant decrease compared to the CFA control group. Leucocyte, erythrocyte and thrombocyte, all 3 groups showed no significant change. In histological observations, all 3 groups were similar to the intact group in terms of synoviocyte, cartilage lacuna and cartilage cells.
Conclusions: The results suggest that warm needling at GB30·GB34, has the effect of suppressing inflammation of CFA-induced rheumatoid arthritis in rats.
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KEYWORD
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Rheumatoid arthritis, Complete Freund’s Adjuvant(CFA), Warm needling, Hwando(GB30), Yangreungcheon(GB34)
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